2- What is AMR ? Antimicrobial resistance requires a global solution For Example:- AIIMS Rishikesh Dept. wise antimicrobial utility data (May 23) MICUTICU (431)CCU 266Neurosurgery ICUPICUMedical-GastroPulmonary MedicineMed-onco & HematED 312Burn & PlasticENTGeneral SxPed SxPed.EDGeriatric wardMedicine wards (1&2)InchargeDr.Mukesh BairwaDr.M Q.AzamDr.Ankit ADr.Rajnesh KumarDr.LokeshDr. Rohit GuptaDr. Girish SindhwaniDr. Uttam NathDr.NidhiDr.Vishal MangoDr. Manu MalhotraDr. Somprakas BasuDr. Satyashree BDr.N.K.BhattDr.Minakshi DharDr RavikantTotal number of patients (N)15111112132213131714144618111442Total Patients on antibiotic (N1)1511111213121313161313381591134N1/N %100%100%100%100%100%100%100%100%94%93%93%82%84%82%78%81% No Antimicrobial (0%)DermatologyOpthalmologyPsychiatryRadiotherapy Genetic variability Selective pressure Vertical transmission Horizontal transmission Foreign DNA can be packaged in:PlasmidsBacteriophagesOther mobile genetic elements Growing population ofresistant bacteria Major mechanisms of resistance